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KMID : 0861020120270030083
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Korea Journal of Herbology
2012 Volume.27 No. 3 p.83 ~ p.88
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Effects of Dendrobii herba against Intracerebral Hemorrhage in Rats
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Lee Jung-Dong
Kim Youn-Sub
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Abstract
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Objects: This study was performed in order to observe the effects of water extract of Dendrobii herba on
intracerebral hemorrhage(ICH),
Methods: ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in
Sprague-Dawley rats. After the water extracts of Dendrobii herba were administrated orally once a day for 3
days, hematoma volume, percentage of brain edema, expression of iNOS and MPO were observed using
immunohistochemistry.
Results: Rats fed with water extracts of Dendrobii herba showed reduction of hematoma volume and
percentage of brain edema compared with controls. In addition, Infiltration of myeloperoxidase (MPO) expressing
neutrophil and expression of inducible nitric oxide synthatase(iNOS) were significantly reduced in rats fed with
water extracts of Dendrobii herba.
Conclusion: These results demonstrated that water extracts of Dendrobii herba reduced brain damage of
intracerebral hemorrhage(ICH) and subsequent ICH-induced cerebral edema, and inhibited neutrophil infiltration.
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KEYWORD
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Dendrobii herba, DH, ICH, iNOS, MPO, Brain Edema
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